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KMID : 1161520050090010001
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Animal Cells and Systems
2005 Volume.9 No. 1 p.1 ~ p.7
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Different way of LMP/TAP/MHC gene clustering in vertebrates, viviparity and anti-tumor immunity failure
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Bubanovic Ivan
Najman Stevo
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Abstract
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Class I and class II MHC genes have been identified in most of the jawed vertebrate taxa. In all investigated bony fish species, unlike mammals, the classical class I and class II MHC genes are not linked and even are found on different chromosomes. Linking and clustering of the class I and class II MHC genes is not the only phenomenon clearly detected in the evolution of immune system from cartilaginous to mammals. In all non?mammalian classes the LMP/TAP genes are highly conserved within class I genes region, while these genes are conserved within class II genes region only in mammals. Today we know that LMP/TAP genes in mammals have a crucial role in peptide processing for presentation within class I molecules, as well as in anti?tumor immunity. For these reasons, differences in clustering of LMP/TAP/MHC genes can be responsible for the differences in mechanisms and efficacy of anti?tumor immunity in non?mammalian vertebrates compared to same mechanisms in mammals. Also, the differences in cytokine network and anti?tumor antigens presentation within classes of vertebrates can be explained by the peculiarity of LMP/TAP/MHC gene clustering.
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KEYWORD
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LMP/TAP/MHC, immunity, vertebrates, mammals, tumor, viviparity
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